Development of novel DNA methyltransferase 1 inhibitors
Development of mechanism-based inhibitors of mammalian/human DNA methyltransferase with IC50 values below 50 nM. The most successful inhibitors will be used for control of functional organization of mammalian genome in research laboratories, biomedical technology, and ultimately in clinics for treatment of pathogenic mechanisms related to epigenetic processes (i.e. tissue regeneration, viral infections, immunological disorders, oncogenesis, pshychiatric and neurological disorders. Read more.